Cancer and therapeutic with hive products

The comprehensive approach to cancer is today a challenge for patients, their families, health teams and society. In most countries of the world, cancer is the first or second cause of premature death only surpassed by cardiovascular disease (1). In spite of the efforts in the timely detection and research of new treatments for the different types of cancer, there are still many challenges to achieve its cure (2), for this reason the search for therapeutic tools aimed at healing, remission, control and achieving a better quality of life in patients suffering from the disease is fully justified. The different products of the hive such as honey, bee venom, pollen, propolis and royal jelly have been shown to have useful properties for the prevention and treatment of cancer in its different grades (3). It is precisely about the mechanisms of action of these products that will be discussed in this article.

Imaging of metastatic cancer cells spreading on the surrounding tissue.

There are more than 100 research articles that have been carried out and that directly explore the mechanisms of action of hive products in cancer. Many of them focus on their effects on breast, prostate, colon, liver and lung cancer, all of them high in the population. Below is a summary of the main mechanisms of action of bee venom, honey and propolis, useful in the treatment of cancer.

Bee venom



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Bibliographic references

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11.        Olsson M, Zhivotovsky B. Caspases and cancer. Cell Death and Differentiation. 2011.

12.        Moon DO, Park SY, Choi YH, Kim ND, Lee C, Kim GY. Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon. 2008;

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16.        Choi KE, Hwang CJ, Gu SM, Park MH, Kim JH, Park JH, et al. Cancer cell growth inhibitory effect of bee venom via increase of death receptor 3 expression and inactivation of NF-kappa B in NSCLC cells. Toxins (Basel). 2014;

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21.        Zafar MK, Eoff RL. Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities. Chem Res Toxicol [Internet]. 2017 Nov 20;30(11):1942–55. Available from:

22.        Aryappalli P, Al-Qubaisi SS, Attoub S, George JA, Arafat K, Ramadi KB, et al. The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells. Front Oncol [Internet]. 2017 Aug 14;7. Available from:

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26.        Mendonsa AM, Na T-Y, Gumbiner BM. E-cadherin in contact inhibition and cancer. Oncogene [Internet]. 2018 Aug 21;37(35):4769–80. Available from:

27.        Hajizadeh Maleki B, Tartibian B, Mooren FC, Krüger K, FitzGerald LZ, Chehrazi M. A randomized controlled trial examining the effects of 16 weeks of moderate-to-intensive cycling and honey supplementation on lymphocyte oxidative DNA damage and cytokine changes in male road cyclists. Cytokine [Internet]. 2016 Dec;88:222–31. Available from:

28.        Reading JL, Gálvez-Cancino F, Swanton C, Lladser A, Peggs KS, Quezada SA. The function and dysfunction of memory CD8 + T cells in tumor immunity. Immunol Rev [Internet]. 2018 May;283(1):194–212. Available from:

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30.        Li H, Kapur A, Yang JX, Srivastava S, McLeod DG, Paredes-Guzman JF, et al. Antiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin. Int J Oncol [Internet]. 2007 Sep;31(3):601–6. Available from:

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34.        Lee Y-J, Kuo H-C, Chu C-Y, Wang C-J, Lin W-C, Tseng T-H. Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochem Pharmacol [Internet]. 2003 Dec;66(12):2281–9. Available from:

35.        Luu TH, Bard J-M, Carbonnelle D, Chaillou C, Huvelin J-M, Bobin-Dubigeon C, et al. Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells. Cell Oncol [Internet]. 2018 Feb 9;41(1):13–24. Available from:

36.        Kimoto T, Aga M, Hino K, Koya-Miyata S, Yamamoto Y, Micallef MJ, et al. Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis. Anticancer Res [Internet]. 21(1A):221–8. Available from:

37.        Zhang B, Wang D, Guo F, Xuan C. Mitochondrial membrane potential and reactive oxygen species in cancer stem cells. Fam Cancer [Internet]. 2015 Mar 30;14(1):19–23. Available from:

38.        Aso K, Kanno S, Tadano T, Satoh S, Ishikawa M. Inhibitory Effect of Propolis on the Growth of Human Leukemia U937. Biol Pharm Bull [Internet]. 2004;27(5):727–30. Available from:

39.        Goldar S, Khaniani MS, Derakhshan SM, Baradaran B. Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment. Asian Pacific J Cancer Prev [Internet]. 2015 Apr 3;16(6):2129–44. Available from:

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