Cancer and therapeutic with hive products

The comprehensive approach to cancer is today a challenge for patients, their families, health teams and society. In most countries of the world, cancer is the first or second cause of premature death only surpassed by cardiovascular disease (1). In spite of the efforts in the timely detection and research of new treatments for the different types of cancer, there are still many challenges to achieve its cure (2), for this reason the search for therapeutic tools aimed at healing, remission, control and achieving a better quality of life in patients suffering from the disease is fully justified. The different products of the hive such as honey, bee venom, pollen, propolis and royal jelly have been shown to have useful properties for the prevention and treatment of cancer in its different grades (3). It is precisely about the mechanisms of action of these products that will be discussed in this article.

Imaging of metastatic cancer cells spreading on the surrounding tissue.

There are more than 100 research articles that have been carried out and that directly explore the mechanisms of action of hive products in cancer. Many of them focus on their effects on breast, prostate, colon, liver and lung cancer, all of them high in the population. Below is a summary of the main mechanisms of action of bee venom, honey and propolis, useful in the treatment of cancer.

Bee venom



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Bibliographic references

1.          World Health Organization. Global Health Estimates 2018: Disease burden by Cause, Sex, by Country and Region, 2000-2016. World Health Organization. 2018.

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3.          Jagua-Gualdrón A. Cáncer Y Terapéutica Con Productos De La Colmena. Revisión Sistemática De Los Estudios Experimentales. Rev la Fac Med [Internet]. 2012;60(2):79–94. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-00112012000200002&lang=pt

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9.          Kessenbrock K, Plaks V, Werb Z. Matrix Metalloproteinases: Regulators of the Tumor Microenvironment. Cell. 2010.

10.        Ip SW, Wei HC, Lin JP, Kuo HM, Liu KC, Hsu SC, et al. Bee venom induced cell cycle arrest and apoptosis in human cervical epidermoid carcinoma Ca Ski cells. Anticancer Res. 2008;

11.        Olsson M, Zhivotovsky B. Caspases and cancer. Cell Death and Differentiation. 2011.

12.        Moon DO, Park SY, Choi YH, Kim ND, Lee C, Kim GY. Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon. 2008;

13.        Yip KW, Reed JC. Bcl-2 family proteins and cancer. Oncogene. 2008.

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16.        Choi KE, Hwang CJ, Gu SM, Park MH, Kim JH, Park JH, et al. Cancer cell growth inhibitory effect of bee venom via increase of death receptor 3 expression and inactivation of NF-kappa B in NSCLC cells. Toxins (Basel). 2014;

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18.        Afrin S, Giampieri F, Gasparrini M, Forbes-Hernández TY, Cianciosi D, Reboredo-Rodriguez P, et al. The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. Food Funct [Internet]. 2018;9(4):2145–57. Available from: http://xlink.rsc.org/?DOI=C8FO00164B

19.        Qie S, Diehl JA. Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med [Internet]. 2016 Dec 2;94(12):1313–26. Available from: http://link.springer.com/10.1007/s00109-016-1475-3

20.        Moskwa J, Borawska MH, Markiewicz-Zukowska R, Puscion-Jakubik A, Naliwajko SK, Socha K, et al. Polish Natural Bee Honeys Are Anti-Proliferative and Anti-Metastatic Agents in Human Glioblastoma multiforme U87MG Cell Line. Pizzo S V., editor. PLoS One [Internet]. 2014 Mar 4;9(3):e90533. Available from: https://dx.plos.org/10.1371/journal.pone.0090533

21.        Zafar MK, Eoff RL. Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities. Chem Res Toxicol [Internet]. 2017 Nov 20;30(11):1942–55. Available from: https://pubs.acs.org/doi/10.1021/acs.chemrestox.7b00157

22.        Aryappalli P, Al-Qubaisi SS, Attoub S, George JA, Arafat K, Ramadi KB, et al. The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells. Front Oncol [Internet]. 2017 Aug 14;7. Available from: http://journal.frontiersin.org/article/10.3389/fonc.2017.00167/full

23.        Yang Y, Liu P, Li D, Yang Q, Li B, Jiang X. Stat‐3 signaling promotes cell proliferation and metastasis of gastric cancer through PDCD4 downregulation. Kaohsiung J Med Sci [Internet]. 2019 Dec 20;kjm2.12159. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/kjm2.12159

24.        Arienti C, Pignatta S, Tesei A. Epidermal Growth Factor Receptor Family and its Role in Gastric Cancer. Front Oncol [Internet]. 2019 Nov 26;9. Available from: https://www.frontiersin.org/article/10.3389/fonc.2019.01308/full

25.        Afrin S, Giampieri F, Gasparrini M, Forbes-Hernández TY, Cianciosi D, Reboredo-Rodriguez P, et al. The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability. Food Funct [Internet]. 2018;9(4):2158–70. Available from: http://xlink.rsc.org/?DOI=C8FO00165K

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27.        Hajizadeh Maleki B, Tartibian B, Mooren FC, Krüger K, FitzGerald LZ, Chehrazi M. A randomized controlled trial examining the effects of 16 weeks of moderate-to-intensive cycling and honey supplementation on lymphocyte oxidative DNA damage and cytokine changes in male road cyclists. Cytokine [Internet]. 2016 Dec;88:222–31. Available from: https://linkinghub.elsevier.com/retrieve/pii/S104346661630521X

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29.        Mrozik KM, Blaschuk OW, Cheong CM, Zannettino ACW, Vandyke K. N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer. BMC Cancer [Internet]. 2018 Dec 1;18(1):939. Available from: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4845-0

30.        Li H, Kapur A, Yang JX, Srivastava S, McLeod DG, Paredes-Guzman JF, et al. Antiproliferation of human prostate cancer cells by ethanolic extracts of Brazilian propolis and its botanical origin. Int J Oncol [Internet]. 2007 Sep;31(3):601–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17671687

31.        Parveen A, Akash MSH, Rehman K, Kyunn WW. Dual Role of p21 in the Progression of Cancer and Its Treatment. Crit Rev Eukaryot Gene Expr [Internet]. 2016;26(1):49–62. Available from: http://www.dl.begellhouse.com/journals/6dbf508d3b17c437,48fcfe1d06fc1851,5776095971b7c1e4.html

32.        Takeda K, Nagamatsu K, Okumura K. A water-soluble derivative of propolis augments the cytotoxic activity of natural killer cells. J Ethnopharmacol [Internet]. 2018 May 23;218:51–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29496576

33.        Morvan MG, Lanier LL. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer [Internet]. 2016 Jan 23;16(1):7–19. Available from: http://www.nature.com/articles/nrc.2015.5

34.        Lee Y-J, Kuo H-C, Chu C-Y, Wang C-J, Lin W-C, Tseng T-H. Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. Biochem Pharmacol [Internet]. 2003 Dec;66(12):2281–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0006295203006270

35.        Luu TH, Bard J-M, Carbonnelle D, Chaillou C, Huvelin J-M, Bobin-Dubigeon C, et al. Lithocholic bile acid inhibits lipogenesis and induces apoptosis in breast cancer cells. Cell Oncol [Internet]. 2018 Feb 9;41(1):13–24. Available from: http://link.springer.com/10.1007/s13402-017-0353-5

36.        Kimoto T, Aga M, Hino K, Koya-Miyata S, Yamamoto Y, Micallef MJ, et al. Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis. Anticancer Res [Internet]. 21(1A):221–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/11299738

37.        Zhang B, Wang D, Guo F, Xuan C. Mitochondrial membrane potential and reactive oxygen species in cancer stem cells. Fam Cancer [Internet]. 2015 Mar 30;14(1):19–23. Available from: http://link.springer.com/10.1007/s10689-014-9757-9

38.        Aso K, Kanno S, Tadano T, Satoh S, Ishikawa M. Inhibitory Effect of Propolis on the Growth of Human Leukemia U937. Biol Pharm Bull [Internet]. 2004;27(5):727–30. Available from: http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/27.727?from=CrossRef

39.        Goldar S, Khaniani MS, Derakhshan SM, Baradaran B. Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment. Asian Pacific J Cancer Prev [Internet]. 2015 Apr 3;16(6):2129–44. Available from: http://koreascience.or.kr/journal/view.jsp?kj=POCPA9&py=2015&vnc=v16n6&sp=2129

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